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After removing 48 duplicates, 112 records remained for screening. Description of Included StudiesĪ total of 160 potentially relevant records were obtained from PubMed ( n = 12), Embase ( n = 43), Cochrane Library ( n = 20), Scopus ( n = 69), Web of Science ( n = 16), and ( n = 0). values 50% and < 0.1) that was unexplained by any subgroup or sensitivity analysis (iv) indirectness was downgraded if there were any influencing factors that limited the interpretation of outcomes and (v) publication bias was downgraded if there was a significant difference in the evidence of publication bias according to either Begg’s test or Egger’s test ( < 0.05). Statistical analysis was performed using STATA 14.0 (StataCorp, College Station, TX, USA) and RevMan 5.3. Begg’s and Egger’s tests were used to examine potential publication bias. In contrast, if outcomes had considerable heterogeneity, sensitivity analysis was performed by omitting one study at a time. For outcomes with small heterogeneity, sensitivity analyses were performed using the conversion effect model. Furthermore, sensitivity analysis was performed to evaluate the robustness of outcomes. Participants (≤60 versus > 60 years), dosage of curcumin supplementation (≥1500 versus 2 months) or sensitivity analysis was conducted to identify the sources of heterogeneity. Curcumin supplementation significantly improved the serum creatinine (WMD: −0.16 mg/dL, 95% CI: −0.3 to −0.02, = 0.029, I 2 = 0%, moderate certainty), total cholesterol (WMD: −10.13 mg/dL, 95% CI: −17.84 to −2.14, = 0.01, I 2 = 0%, moderate certainty), systolic blood pressure (WMD: 3.94 mmHg, 95% CI: 1.86 to 6.01, 50%, and >75% were considered to indicate low, moderate, and high heterogeneity, respectively. Five RCTs involving 290 participants with DKD were included. Statistical analysis was performed using STATA 14.0 and RevMan 5.3. Weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated to describe the effect sizes using a fixed-effect model. Two investigators independently extracted data and assessed the risk of bias. A systematic and comprehensive literature search of interrelated randomized controlled trials (RCTs) was conducted in PubMed, Embase, Cochrane Library, Web of Science, Scopus, and from inception to July 30, 2021. This systematic review and meta-analysis aimed to investigate the effect of curcumin supplementation on renal function, lipid profile, blood pressure, and glycemic control in DKD. Curcumin, a polyphenolic constituent from Curcuma longa, possesses antioxidant, hypolipidemic, and antidiabetic properties and has been reported to protect against diabetic kidney disease (DKD) however, the effect is inconsistent. Load up Serum and we think you’ll be able to notice both what you hear (solid high frequencies, extending flat all the way up to the limits of hearing) as well as what you don’t hear (no unwanted mud or aliasing gibberish- just good, clean sound).Background. In Serum, the native-mode (default) playback of oscillators operates with an ultra high-precision resampling, yielding an astonishingly inaudible signal-to-noise (for instance, -150 dB on a sawtooth played at 1 Khz at 44100)! This requires a lot of calculations, so Serum’s oscillator playback has been aggressively optimized using SSE2 instructions to allow for this high-quality playback without taxing your CPU any more than the typical (decent quality) soft synth already does. Many popular wavetable synthesizers are astonishingly bad at suppressing artifacts - even on a high-quality setting some create artifacts as high as -36 dB to -60 dB (level difference between fundamental on artifacts) which is well audible, and furthermore often dampening the highest wanted audible frequencies in the process, to try and suppress this unwanted sound. Artifacts mean that you are (perhaps unknowingly) crowding your mix with unwanted tones / frequencies. Without considerable care and a whole lot of number crunching, this process will create audible artifacts. Playback of wavetables requires digital resampling to play different frequencies.